SERPINF2 (serpin family F member 2) is a serine protease inhibitor that primarily targets plasmin and trypsin, playing a crucial role in regulating fibrinolysis and hemostasis. As a key component of the coagulation cascade, SERPINF2 functions by inhibiting plasmin-mediated fibrin degradation, thereby preventing excessive fibrinolysis 1. The protein is significantly associated with coagulation disorders, particularly alpha-2-plasmin inhibitor deficiency, where loss-of-function mutations in SERPINF2 cause accelerated fibrinolysis and bleeding disorders 21. Clinically, SERPINF2 serves as an important biomarker in various pathological conditions. Elevated plasma levels have been identified as a predictor of 28-day mortality in severe burn patients, with ROC analysis showing AUC > 0.8 3. In preeclampsia, SERPINF2 expression is regulated by steroid hormones, with testosterone upregulating and estradiol downregulating its expression, contributing to the hypercoagulation status observed in this condition 4. The protein also shows altered expression in gastric cancer, where it functions as part of complement system-related prognostic signatures 5. SERPINF2's expression can be modulated therapeutically, as demonstrated by Hanfangji compound's ability to upregulate SERPINF2 in hepatic stellate cells 6.