SH3GLB1 (endophilin B1) is a multifunctional membrane curvature-inducing protein that plays critical roles in autophagy, mitochondrial dynamics, and apoptosis regulation. The protein functions as a key regulator of autophagy by interacting with the PIK3C3 complex II and facilitating ATG9A trafficking from the Golgi to form autophagosomes 1. SH3GLB1 is essential for mitophagy, the selective autophagy of damaged mitochondria, and its deficiency leads to mitochondrial accumulation and impaired mitochondrial clearance 12. In cancer contexts, SH3GLB1 exhibits tumor suppressor functions, with reduced expression associated with poorer survival outcomes across multiple cancer types 3. The protein regulates glioblastoma stem cell characteristics by controlling CD133 expression through histone H4K5 acetylation modifications 4 and is required for NOTCH2 activation in hypoxic glioblastoma environments 5. SH3GLB1 undergoes SUMO2-mediated SUMOylation, which promotes mitophagy activation and contributes to ionizing radiation-induced cardiac hypertrophy 2. As a haploinsufficient tumor suppressor, SH3GLB1 loss enhances chr1 instability and apoptosis resistance during oncogene-driven transformation 1. The protein's dysfunction has been implicated in cardiovascular disease and identified as a potential biomarker for schizophrenia risk 6.