SIRT1 is a highly conserved NAD+-dependent histone deacetylase that functions as a critical regulator of cellular metabolism, aging, and inflammation 1. As the primary enzyme in the sirtuin family, SIRT1 operates by deacetylating both histone and non-histone proteins to modulate gene expression and cellular processes 1. The protein plays a central role in aging-related pathways by regulating key signaling networks including NF-κB, AMPK, mTOR, P53, PGC-1α, and FoxOs 2. SIRT1's deacetylation of PGC-1α is particularly important for metabolic control and mitochondrial biogenesis, linking it to caloric restriction responses and longevity 3. The enzyme also regulates autophagy through deacetylation of FOXOs, ATGs, and LC3, which is crucial during cellular stress conditions 4. SIRT1 expression decreases with aging, while increased expression extends lifespan across multiple species 2. Clinically, SIRT1 alterations are linked to inflammatory diseases, cardiovascular pathologies, neurodegenerative disorders, and diabetic complications 15. The protein shows therapeutic potential, with various nutraceuticals and compounds capable of enhancing SIRT1 activity for treating age-related diseases 67.