SIRT2 is a cytoplasmic NAD+-dependent deacetylase that plays crucial roles in aging, metabolism, and cellular homeostasis through post-translational modification of key regulatory proteins. The enzyme functions by deacetylating specific lysine residues on target proteins, including STAT3 in cardiomyocytes 1, p66Shc in vascular tissues 2, MLH1 in colorectal cancer cells 3, septin4 in kidney podocytes 4, and LDHA in ovarian granulosa cells 5. SIRT2 expression and activity decline with aging across multiple tissues, contributing to age-related pathologies 21. The protein regulates diverse cellular processes including mitotic fidelity through BubR1 regulation 6, metabolic homeostasis via glycolysis modulation 57, and immune surveillance by controlling DNA repair mechanisms 3. Clinically, SIRT2 deficiency is associated with accelerated vascular aging, cardiac dysfunction, and altered tumor immunity, while its therapeutic targeting shows promise for treating osteoporosis 8, hypertensive nephropathy 4, and enhancing cancer immunotherapy 3. The enzyme's dependence on NAD+ availability links cellular energy status to epigenetic regulation and aging processes.