SKA2 (spindle and kinetochore associated complex subunit 2) is a multifunctional protein with roles extending beyond its classical cell cycle functions. As a component of the SKA complex, SKA2 is essential for proper chromosome 17 during mitosis and facilitates microtubule binding at the kinetochore-microtubule interface 12. However, emerging evidence reveals SKA2's involvement in stress-related neurobiological processes through its interaction with glucocorticoid receptor (GR) signaling. SKA2 enhances GR function by promoting GR-FKBP4 interactions while facilitating FKBP5 dissociation, thereby regulating hypothalamic-pituitary-adrenal axis responsiveness 3. Additionally, SKA2 regulates secretory autophagy-dependent IL-1β release from microglia, with its dysfunction leading to neuroinflammation and neurodegeneration 4. Clinically, SKA2 shows significant disease relevance across multiple conditions. Aberrant SKA2 expression and epigenetic modifications are associated with depression and stress-related disorders 5, while increased expression correlates with suicide risk 6. In oncology, SKA2 overexpression promotes breast cancer metastasis through epithelial-mesenchymal transition pathways 78 and contributes to lung cancer progression 9. SKA2 polymorphisms also serve as biomarkers for preterm birth prediction, linking stress responses to reproductive outcomes 10.