SKA3 (spindle and kinetochore associated complex subunit 3) is a component of the outer kinetochore that plays essential roles in chromosome 13 during cell division and has emerged as a significant oncogene in multiple cancers. As part of the SKA1 complex, SKA3 directly binds microtubules and facilitates proper chromosome 13 by enabling processive movement along depolymerizing microtubules 123. Beyond its mitotic functions, SKA3 exhibits oncogenic properties through diverse mechanisms. In cholangiocarcinoma, hypoxia-induced SKA3 promotes tumor progression by recruiting PARP1 to enhance HIF-1α PARylation, leading to HIF-1α stabilization and increased fatty acid synthesis 4. In lung adenocarcinoma, SKA3 facilitates metastasis through multiple pathways: it promotes hypoxia tolerance by disrupting PHD2-HIF-1α interactions, enabling metabolic reprogramming for liver colonization 5, and creates an EGFR/E2F1/SKA3/integrin β1 signaling loop that enhances cell migration and invasion 6. SKA3 is consistently overexpressed across various cancers including non-small cell lung cancer 7 and gastric cancer 8, correlating with poor patient prognosis 9. These findings establish SKA3 as both a potential diagnostic biomarker and therapeutic target, representing a promising avenue for precision cancer treatment 10.