Based on limited published evidence, SKIC8 is a component of the PAF1 complex (PAF1C) regulating RNA polymerase II transcription, particularly of Hox and Wnt genes, and controlling histone modifications including H2B ubiquitination and H3K4 methylation 123. SKIC8 also functions as a SKI complex component facilitating mRNA degradation by extracting transcripts from stalled ribosomes and channeling them to the exosome 45. Recent evidence suggests SKIC8 is a therapeutic target for broad-spectrum antiviral intervention, with SKI complex inhibition upregulating cellular cholesterol synthesis to restrict viral replication 6.