SLC16A7 encodes monocarboxylate transporter 2 (MCT2), a proton-coupled symporter that facilitates the rapid transport of monocarboxylates including L-lactate, pyruvate, and ketone bodies across plasma membranes 1. The protein requires dimerization for functional activity, with both subunits working cooperatively in substrate transport 1. SLC16A7/MCT2 plays crucial roles in neurometabolic coupling, where it facilitates lactate transport in neurons as part of the neuron-astrocyte metabolic relationship 2. The transporter is essential for brain energy metabolism and shows tissue-specific distribution patterns appropriate for various metabolic functions 1. In disease contexts, SLC16A7 demonstrates tumor suppressive properties in bladder cancer, with downregulation associated with poor prognosis and reduced immune cell infiltration 3. Conversely, in prostate cancer, MCT2 is overexpressed due to selective demethylation of internal promoters, contributing to oncogenic signaling pathways 4. The gene shows potential therapeutic relevance, as RPE-specific MCT2 expression promotes cone survival in retinitis pigmentosa models by facilitating lactate transport and glucose metabolism 5. Additionally, SLC16A7 genetic variations may modulate dietary intervention effects on brain health in older adults 6.