BSG (basigin/CD147) is a cell surface receptor that functions primarily as a multifunctional adhesion molecule and mediates intercellular communication. The protein facilitates homophilic cell-cell adhesion and serves as a receptor for extracellular ligands, including cyclophilin A, which activates downstream signaling pathways 1. BSG is distributed across multiple cellular compartments including the basolateral plasma membrane, endoplasmic reticulum, Golgi apparatus, endosomes, and extracellular exosomes, enabling its involvement in diverse biological processes 2. The protein plays important roles in developmental processes, including angiogenesis, embryo implantation, and neurite outgrowth, as well as vascular tube morphogenesis. In viral pathogenesis, BSG functions as an alternative entry receptor for SARS-CoV-2 alongside ACE2, with expression documented in human oocytes and ocular tissues, raising concerns about potential viral infection of reproductive cells and ocular complications 34. Clinically, BSG is significant in cancer biology, where its overexpression correlates with poor prognosis, increased metastatic potential, therapeutic resistance, and stem-like properties in cancer cells 1. The CypA/CD147 interaction represents a promising therapeutic target for anticancer treatment, with elevated PPIA/BSG expression associated with reduced survival rates and advanced cancer stages across multiple tumor types.