SLC22A24 is an orphan solute carrier transporter that was recently deorphaned and identified as a mediator of steroid conjugate transport 1. Although UniProt annotations indicate a lack of transporter activity, functional studies demonstrate that SLC22A24 facilitates transport of steroid conjugates and bile acids, with a specialized role in kidney function and organic anion reabsorption 1. Genome-wide association studies revealed that genetic variants in SLC22A24 are significantly associated with androsterone glucuronide and etiocholanolone glucuronide levels (p<1×10⁻³⁰), establishing its role in steroid homeostasis 1. Phylogenetic classification places SLC22A24 within the OATS4 subgroup of organic anion transporters, alongside SLC22A9, SLC22A10, and SLC22A25, with particular specificity for conjugated sex hormones 2. Beyond steroid transport, SLC22A24 also functions as a thyroid hormone analog transporter, facilitating intracellular accumulation of 3,3',5-triiodothyroacetic acid (TRIAC) in the presence of serum albumin, suggesting therapeutic potential in MCT8 deficiency treatment 3. Functional variants in SLC22A24 show phenome-wide associations with cardiovascular disease and acne, conditions linked to dysregulated steroid metabolism, implicating this transporter as a potential pharmacological target for modulating steroid levels 1.