SLC25A11 encodes a mitochondrial inner membrane transporter that catalyzes the electroneutral exchange of 2-oxoglutarate for malate and other dicarboxylic acids, playing crucial roles in cellular metabolism and mitochondrial function. The protein facilitates mitochondrial glutathione transport, which is essential for maintaining mitochondrial glutathione levels and protecting against oxidative stress 12. SLC25A11 participates in key metabolic pathways including the malate-aspartate shuttle and contributes to ATP generation by regulating NADH transportation from cytoplasm to mitochondria 3. The protein's stability and function are regulated through post-translational modifications, including deubiquitination by OTUD1 4 and m6A methylation affecting its mRNA stability 5. SLC25A11 dysfunction is implicated in various diseases, including its role in ferroptosis regulation where depletion leads to mitochondrial glutathione loss and subsequent cell death 25. The gene serves as a prognostic biomarker in liver cancer, with low expression associated with poor survival outcomes 3. Additionally, germline variants in SLC25A11 have been identified in Carney-Stratakis syndrome, characterized by pheochromocytomas and gastrointestinal stromal tumors 6, establishing its clinical significance in tumor predisposition syndromes.