SLC2A10 encodes GLUT10, a facilitative glucose transporter that plays a critical role in cardiovascular system development and connective tissue integrity 1. The protein maintains the characteristic 12 transmembrane domain structure of glucose transporters and is highly expressed in liver and pancreas 12. SLC2A10 functions in glucose transport across plasma membranes and exhibits broad expression patterns during embryonic development, with maternal mRNA detected ubiquitously until early somitogenesis, followed by tissue-specific expression in structures including otic vesicles, pectoral fins, and swim bladder 1. Mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), a rare autosomal recessive connective tissue disorder characterized by severe tortuosity and elongation of large and medium-sized arteries, propensity for aneurysm formation, and cardiovascular complications 34. ATS patients also display connective tissue features including hyperextensible skin, joint hypermobility, and distinctive facial features 3. The gene is associated with hereditary large vessel diseases and disrupts transforming growth factor-β signaling pathways critical for vascular integrity 5. While investigated as a candidate for type 2 diabetes due to its glucose transporter function and chr20 location, studies have not confirmed significant associations 26.