SLC2A11 encodes GLUT11, a facilitative glucose transporter that belongs to the class II sugar transport facilitator family and shows highest similarity to the fructose transporter GLUT5 1. The gene generates three isoforms (GLUT11-A, -B, and -C) through alternative promoter usage, with tissue-specific expression patterns: GLUT11-A in heart, skeletal muscle, and kidney; GLUT11-B in kidney, adipose tissue, and placenta; and GLUT11-C in adipose tissue, heart, skeletal muscle, and pancreas 1. When expressed in Xenopus oocytes, all three isoforms transport glucose and fructose but not galactose, with glucose transport activity markedly inhibited by fructose 12. The protein contains 12 putative transmembrane helices and essential sugar-transporter signatures 2. SLC2A11 has been implicated in various pathological conditions, including prolactin pituitary tumor metastasis where it shows upregulated expression 3, and cervical cancer where the chimeric RNA SLC2A11-MIF affects cell cycle arrest and proliferation 4. The gene is also included in lipid metabolism-related prognostic models for diffuse large B-cell lymphoma 5 and may play a role in pigmentation adaptation in desert lizards 6.