SLC2A14 encodes GLUT14, a facilitated glucose transporter that mediates the transport of both glucose and dehydroascorbic acid (vitamin C) across cell membranes 1. The protein localizes to the plasma membrane 1 and functions as a bidirectional transporter for these substrates in mammalian cells 2. While originally characterized as testis-specific, SLC2A14 demonstrates broader tissue expression 1 and is expressed during early embryonic development 3. Geneticallyanchored variations in SLC2A14 associate with multiple chr12 diseases. Polymorphisms in the gene increase susceptibility to late-onset Alzheimer's disease, with the rs10845990 G-allele conferring a 1.41-fold increased risk in Han Chinese populations 4. Three independent SLC2A14 variants (rs2889504-T, rs10846086-G, rs12815313-T) significantly elevate inflammatory bowel disease risk, with odds ratios ranging from 1.61 to 4.68 2. The gene also emerges as a ferroptosis-related marker associated with periodontitis development 5 and intervertebral disc degeneration through glucose-deprivation mechanisms 6. Epigenetically, SLC2A14 methylation patterns differ between psychiatric patients and controls exposed to perinatal asphyxia, linking the gene to schizophrenia and bipolar disorder risk 7. These disease associations suggest that impaired glucose and antioxidant transport contribute to pathological processes in neurodegeneration, inflammation, and metabolic dysfunction.