SLC2A2 encodes GLUT2, a facilitative glucose transporter that plays critical roles in glucose homeostasis and sensing. GLUT2 mediates bidirectional transport of glucose, fructose, and galactose across plasma membranes and is expressed in key metabolic tissues including liver, pancreatic beta cells, kidney, and intestine 1. In pancreatic beta cells, GLUT2 is essential for glucose-stimulated insulin secretion and comprises part of the glucose-sensing mechanism 1. The transporter also participates in renal glucose reabsorption via the basolateral membrane of proximal tubules, working alongside SGLT1 and SGLT2 to prevent glucose loss in urine 2. In the intestine, GLUT2 contributes to glucose absorption and barrier function, with hyperglycemia-induced GLUT2 activity leading to intestinal permeability and increased infection risk 3. Inactivating mutations in SLC2A2 cause Fanconi-Bickel syndrome, characterized by hepatomegaly and kidney disease 1. Genome-wide association studies have linked SLC2A2 variants to fasting glucose levels, type 2 diabetes risk, and cardiovascular diseases 41. Additionally, SLC2A2 polymorphisms influence metformin efficacy in type 2 diabetes treatment and dental caries susceptibility 56.