SLC2A7 (GLUT7) is a facilitated glucose transporter that mediates high-affinity transport of glucose (Km = 0.3 mM) and fructose across cell membranes 1. The protein belongs to class II of the GLUT family and shares 68% similarity with GLUT5, its closest family member 1. SLC2A7 is predominantly expressed in the small intestine and colon, with additional expression in testis and prostate 1. The transporter localizes to the apical brush-border membrane of enterocytes, where its expression changes in parallel with dietary carbohydrate intake 2. Functionally, GLUT7 transports glucose and fructose but does not transport galactose, 2-deoxy-D-glucose, or xylose 1. The cryo-EM structure reveals a typical major facilitator superfamily fold with the substrate-binding site open to the extracellular side, undergoing rocker-switch-like conformational changes for substrate translocation 3. Clinically, SLC2A7 has emerged as a prognostic biomarker for lung adenocarcinoma, with expression linked to cancer cell viability and migration 45. Despite its intestinal abundance, the physiological substrate remains subject to discussion, as its distribution doesn't entirely match glucose and fructose availability patterns 2.