SLC2A6 (GLUT6) is a glucose transporter family member that functions as a regulator of cellular metabolism and ferroptosis rather than a conventional glucose transporter. Unlike other glucose transporters, SLC2A6 does not transport glucose but instead acts as a probable sugar transporter that regulates glycolysis in macrophages 1. The protein plays crucial roles in ferroptosis regulation across multiple cell types and disease contexts. In macrophages, SLC2A6 expression is associated with ferroptosis pathways and inflammatory responses 2. In cancer, particularly hepatocellular carcinoma and breast cancer, SLC2A6 functions as a tumor suppressor by modulating ferroptosis, with knockdown promoting cell proliferation and migration while overexpression inhibits these processes 34. The gene also shows dysregulated expression in polycystic ovary syndrome, where it correlates with oocyte quality parameters and is involved in lysosomal function 56. In pancreatic islets, SLC2A6 is upregulated in obesity and diabetes, where it negatively regulates insulin secretion 7. Additionally, SLC2A6 expression is regulated by NF-κB signaling, particularly through TNFα-induced RELA activation 8. These findings establish SLC2A6 as a metabolic regulator with significant roles in ferroptosis, cancer progression, and metabolic diseases.