SLC37A1 is a phosphate-linked glucose-6-phosphate antiporter localized to the endoplasmic reticulum (ER) membrane 1. The protein catalyzes bidirectional exchange of glucose-6-phosphate and inorganic phosphate across the ER membrane, functioning as both a homologous (phosphate/phosphate) and heterologous (glucose-6-phosphate/phosphate) exchanger 2. SLC37A1 shares significant sequence homology with bacterial glycerol-3-phosphate permeases and may also transport glycerol-3-phosphate, a critical substrate for phospholipid biosynthesis 2. Unlike SLC37A4 (G6PT), SLC37A1 cannot functionally couple with glucose-6-phosphatase-α or -β and is insensitive to chlorogenic acid inhibition, indicating distinct physiological roles independent of blood glucose homeostasis 3. SLC37A1 expression is upregulated by epidermal growth factor in breast cancer cells through EGFR/MAPK/Fos signaling, suggesting involvement in tumor lipid biosynthesis 4. In cattle, SLC37A1 variants associate with milk protein phosphorylation patterns, linking the transporter to phosphorus metabolism regulation 5. Unlike SLC37A4 deficiency, which causes glycogen storage disease type Ib, no disease associations have been established for SLC37A1 mutations to date 6. The biological function of SLC37A1 remains incompletely characterized and requires further investigation.