SLC39A10 (ZIP10) is a zinc-influx transporter localized to the plasma membrane that mediates cellular zinc uptake across multiple tissues 1. Beyond basic zinc homeostasis, SLC39A10 plays critical roles in immune regulation, cellular proliferation, and development. In T cells, SLC39A10 serves as a key zinc importer upon T cell receptor activation, safeguarding DNA replication; its loss protects against autoimmune diseases including inflammatory bowel disease and experimental autoimmune encephalomyelitis 2. In oocytes and endometrial tissue, SLC39A10 is essential for early embryonic development and successful pregnancy establishment through zinc-dependent signaling pathways 34. Clinically, SLC39A10 dysregulation is associated with malignancy. In osteosarcoma, ZIP10 overexpression drives proliferation and chemoresistance via the ITGA10-mediated PI3K/AKT pathway 5. In gastric cancer, SLC39A10 upregulation correlates with poor prognosis and activates CK2-mediated MAPK/ERK and PI3K/AKT signaling 6. A novel STAT3 inhibitor suppresses gastric cancer growth through dual inhibition of MYC and SLC39A10 7. In esophageal squamous cell carcinoma, P. gingivalis infection downregulates SLC39A10 expression through a HuR-dependent circular RNA mechanism 8. These findings establish SLC39A10 as both a therapeutic target and a potential biomarker for cancer management.