SLC7A10 (ASC-1) is a sodium-independent neutral amino acid transporter that plays critical roles in both neural and metabolic functions. The protein catalyzes transport of neutral amino acids including glycine, L-serine, D-serine, and alanine across cell membranes 1. In the central nervous system, SLC7A10 is highly expressed in astrocytes of the spinal cord and caudal brain, where it maintains glycine levels essential for glycinergic inhibitory neurotransmission in motor neurons 2. Loss of SLC7A10 function causes sustained myoclonus and early postnatal lethality in mice due to impaired glycinergic inhibition 2. In adipose tissue, SLC7A10 serves as a key metabolic regulator, with expression levels inversely correlating with insulin resistance, adipocyte size, and type 2 diabetes risk 34. The transporter promotes serine uptake and glutathione production, reducing reactive oxygen species generation and supporting mitochondrial respiratory capacity in adipocytes 4. SLC7A10 deficiency increases lipid accumulation and alters branched-chain amino acid metabolism, potentially contributing to insulin resistance 5. These findings establish SLC7A10 as a critical transporter linking amino acid metabolism to neurological function and metabolic health.