2 sources retrieved · Most recent: April 2026 · Index updated 14 days ago
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78PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
protein bindingnucleolusmaturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)90S preribosomealcohol drinkingsuppurative periapical periodontitisVertigospontaneous coronary artery dissection
Based on limited published evidence, SLX9 is a ribosome biogenesis factor localized to the nucleolus that mediates protein-protein interactions. SLX9 functions as a nuclear export factor for pre-40S ribosomal subunits, associating with maturing pre-40S complexes in the nucleoplasm to confer export competence prior to cytoplasmic release 1. The protein operates within the coordinated assembly pathway following dissociation of 90S precursor factors and repositioning of other assembly factors like RRP12 and TSR1.
1
SLX9 functions as an export factor that associates with pre-40S ribosomal subunits during nucleoplasmic maturation to provide export competence for nuclear export
PMID: 36321656⚠Limited data available — This gene has 1 indexed publication. Summary and analysis may be incomplete.
alcohol drinkingOpen Targets
suppurative periapical periodontitisOpen Targets
spontaneous coronary artery dissectionOpen Targets
lung adenocarcinomaOpen Targets
ovarian neoplasmOpen Targets
autosomal recessive nonsyndromic hearing loss 9Open Targets
amyotrophic lateral sclerosisOpen Targets
autosomal dominant nonsyndromic hearing lossOpen Targets
benign adult familial myoclonic epilepsyOpen Targets
hearing loss, autosomal recessiveOpen Targets
acute myeloid leukemiaOpen Targets
clear cell renal carcinomaOpen Targets
No pathogenic variants reported on ClinVar for this gene.