SNX10 is a phosphoinositide-binding protein that functions as a critical regulator of endosomal trafficking and cellular homeostasis. The protein localizes to early endocytic compartments in a PtdIns3P-dependent manner and modulates protein sorting between endosomes and other cellular compartments 1. SNX10 plays essential roles in multiple cellular processes, including regulation of mitochondrial bioenergetics by negatively modulating piecemeal mitophagy of OXPHOS machinery components 1. In cancer biology, SNX10 affects HER2 trafficking by regulating endosomal RAB11A, with deficiency leading to increased HER2 lysosomal degradation and reduced cell-surface expression 2. The protein also mediates macrophage metabolic reprogramming in atherosclerosis through the Lyn-dependent TFEB signaling pathway 3. Clinically, SNX10 mutations cause autosomal recessive osteopetrosis, a rare bone disease characterized by dense, fragile bones due to osteoclast dysfunction 45. SNX10 deficiency in zebrafish results in elevated ROS levels and ROS-mediated neuronal death, demonstrating its importance in maintaining cellular redox homeostasis 1. These diverse functions establish SNX10 as a multifunctional protein essential for normal cellular trafficking, metabolism, and bone homeostasis.