SNX2 (sorting nexin 2) is a peripheral membrane protein that functions as a key component of the mammalian retromer complex, mediating intracellular cargo trafficking. SNX2 contains phosphatidylinositol binding PX and BAR domains that enable interaction with curved endosomal membranes enriched in PI(3)P and PI(3,5)P2 1. As part of the SNX-BAR retromer subcomplex, SNX2 associates with the Vps26-Vps29-Vps35 cargo-recognition trimer to mediate retrograde transport from endosomes to the trans-Golgi network (TGN) and facilitate recycling of cargo proteins to the plasma membrane 2. SNX1 and SNX2 play interchangeable but essential roles in retromer assembly and function, with either protein capable of recruiting the core Vps complex to endosomes and enabling mannose 6-phosphate receptor retrieval 3. Beyond retromer function, SNX2 promotes KALRN- and RHOG-dependent membrane remodeling independent of retromer activity, including lamellipodium formation. SNX2 participates in endosomal recycling domain assembly through interaction with the WASH complex, contributing to dynamic regulation of endosomal trafficking. Beyond trafficking, SNX2 interacts with influenza A virus PA protein and negatively regulates viral replication 4. SNX2 dysregulation has been observed in congenital myasthenic syndrome and associated with chr5 myeloid leukemia translocations, indicating clinical relevance in neuromuscular and hematologic disease.