SNX8 (sorting nexin 8) is a BAR domain-containing endosomal protein that functions as a multifaceted regulator of intracellular trafficking and cellular homeostasis. As a retromer complex component, SNX8 mediates early endosome-to-trans-Golgi network transport and endosomal sorting through phosphatidylinositol 3-phosphate (PI(3)P)-dependent membrane binding 1. Beyond basic trafficking, SNX8 exhibits diverse disease-relevant functions: it promotes lysosome tubulation and reformation, with SNX8 overexpression and small-molecule enhancers of SNX8-lysosome binding reversing lysosomal storage disorder phenotypes in cells and mice 2. SNX8 regulates fatty acid synthase (FASN) protein stability by recruiting the E3 ubiquitin ligase TRIM28, thereby suppressing hepatic de novo lipogenesis and providing protection against nonalcoholic fatty liver disease 34. In Alzheimer's disease, decreased SNX8 expression correlates with increased amyloid-β accumulation; SNX8 overexpression enhances non-amyloidogenic APP processing and rescues cognitive deficits in AD mice 5. SNX8 also functions in innate immunity by linking IFNγ receptor signaling to IKKβ-mediated gene induction, critical for host defense against intracellular pathogens 6. Additionally, SNX8 controls pathogen-induced membrane dynamics during bacterial infection 7. Notably, SNX8 epitopes cross-react with SARS-CoV-2 nucleocapsid protein, implicating SNX8 in post-infectious inflammatory complications 8. These findings position SNX8 as a therapeutic target across metabolic, neurodegenerative, and infectious disease contexts.