SNX20 (sorting nexin 20) is a member of the sorting nexin family that functions in endosomal vesicle trafficking and cellular transport processes. SNX20 belongs to the SNX-PXB protein subgroup, containing a PX-associated B (PXB) domain that likely enables scaffolding functions on endosomal membranes 1. The protein has been proposed to target SELPLG into endosomes without affecting its cell surface internalization or cell-cell adhesion functions. SNX20 shows significant disease relevance across multiple cancer types, with context-dependent roles. In lung adenocarcinoma, SNX20 is downregulated and functions as a tumor suppressor, where overexpression inhibits cell proliferation and migration 2. This downregulation appears to be mediated by DNA hypermethylation and the SNX20AR/miRNA-301a-3p regulatory axis 2. Conversely, in low-grade glioma, SNX20 is overexpressed due to DNA hypomethylation and correlates with poor prognosis and tumor progression 3. SNX20 is also associated with immune cell infiltration and inflammatory responses across cancers 34. Additionally, SNX20 variants show linkage disequilibrium with NOD2 and are associated with Crohn's disease risk in African Americans 5. These findings suggest SNX20 plays complex, tissue-specific roles in cancer biology and immune regulation.