SORBS1 encodes a cytoskeletal adaptor protein that plays critical roles in insulin signaling and vascular development. The protein contains a sorbin homology domain and three SH3 domains, functioning as an important adaptor in insulin-stimulated glucose transport by linking CBL to the insulin receptor 1. SORBS1 undergoes extensive alternative splicing, producing multiple isoforms ranging from 81.5 to 142.2 kDa, with tissue-specific expression patterns 1. Mechanistically, SORBS1 controls FAK/Src signaling and regulates cytoskeletal processes through Rac1 and RhoA GTPases, impacting cell-ECM contacts and cytoskeleton dynamics 2. The protein is essential for vascular development, particularly controlling secondary sprouting from axial veins and lymphatic vessel formation in zebrafish 2. Genetic variants of SORBS1 show significant clinical relevance, with the T228A polymorphism associated with protection against obesity and type 2 diabetes 3, while other variants influence glucose homeostasis, diabetes onset age 4, and blood pressure regulation 5. Additionally, SORBS1 alternative splicing defects contribute to neuromuscular junction degeneration in myotonic dystrophy type 1, highlighting its importance in neuromuscular system integrity 6. The protein also shows neuroprotective roles in insulin resistance-related neurodegeneration 7.