SOX7 is a transcription factor belonging to the SOX family that plays critical roles in developmental and pathological processes. During embryonic development, SOX7 regulates hematopoiesis, vasculogenesis, and cardiogenesis 1. It functions as a transcriptional activator of CDH5 and other endothelial genes, while repressing Wnt/β-catenin signaling by targeting β-catenin for degradation 2. SOX7 is essential for hemogenic endothelium specification and survival of hematopoietic and endothelial precursors 3. In cancer biology, SOX7 functions as a tumor suppressor. Its expression is frequently downregulated across multiple cancer types including prostate, colon, lung, breast, and bladder cancers, correlating with poor prognosis 1. SOX7 reduces cancer cell proliferation, migration, and invasion; in bladder cancer, it inhibits malignant progression via the DNMT3B/CYGB axis 4. In hematological malignancies, SOX7 loss-of-function through methylation-mediated silencing promotes tumorigenesis 5. Furthermore, SOX7 suppresses hepatic stellate cell activation and liver fibrosis by attenuating Wnt/β-catenin and TGF-β/Smad signaling 6. Clinically, SOX7 represents a promising therapeutic target for cancer and fibrotic diseases, though SOX7-mediated transcriptional mechanisms in disease contexts require further investigation 1.