1 sources retrieved · Most recent: April 2026 · Index updated 16 days ago
ⓘGeneE is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment.
20PubMed Papers
20Diseases
0Drugs
0Pathogenic Variants
DATA QUALITY✓ Experimental GO Evidence✓ Swiss-Prot Reviewed
protein-macromolecule adaptor activitytype 1 diabetes mellitushypertensiondiabetes mellitushypertension, pregnancy-induced
Based on limited published evidence, SPRYD3 is a protein-macromolecule adaptor that functions as a substrate specificity factor in E3 ubiquitin ligase complexes. SPRYD3 associates with MYCBP2 to form an E3 ligase complex that regulates mitotic cell fate and spindle assembly 1. The SPRYD3-MYCBP2 complex promotes bipolar spindle formation by catalyzing non-canonical ubiquitination of the deubiquitinase USP11 at cysteine 318, facilitating mitotic slippage during microtubule stress 1.
1
SPRYD3 functions as a substrate specificity factor in an E3 ubiquitin ligase complex with MYCBP2 that regulates mitotic spindle assembly and cell fate decisions through USP11 ubiquitination
PMID: 41052634⚠Limited data available — This gene has 1 indexed publication. Summary and analysis may be incomplete.
type 1 diabetes mellitusOpen Targets
diabetes mellitusOpen Targets
hypertension, pregnancy-inducedOpen Targets
osteoarthritis, kneeOpen Targets
cardiovascular diseaseOpen Targets
Familial exudative vitreoretinopathyOpen Targets
retinitis pigmentosaOpen Targets
ankylosing spondylitisOpen Targets
birdshot chorioretinopathyOpen Targets
snowflake vitreoretinal degenerationOpen Targets
Coats diseaseOpen Targets
exudative vitreoretinopathy 2, X-linkedOpen Targets
exudative vitreoretinopathyOpen Targets
retinitis pigmentosa 86Open Targets
Rare isolated myopiaOpen Targets
ocular cystinosisOpen Targets
Alpha-methylacyl-CoA racemase deficiencyOpen Targets
Congenital bile acid synthesis defect type 4Open Targets
No pathogenic variants reported on ClinVar for this gene.