SST (somatostatin) encodes a cyclic peptide hormone that functions as a negative regulator of cell proliferation and hormone release through activation of somatostatin receptors (SSTRs) 1. The peptide exhibits high binding affinity to all five SSTR subtypes and mediates diverse physiological functions 1. In the nervous system, SST serves as an important homeostatic regulator with robust antiepileptic properties, primarily acting in the hippocampus where it is highly expressed in seizure-associated brain regions 2. SST expression and release are regulated by seizures, and SST-containing neurons in the dentate gyrus are particularly vulnerable to seizure-induced death 2. The peptide's antiepileptic actions are mediated through SSTR2 and SSTR4 receptors, making these receptors potential targets for antiepileptic drug development 2. SST is also expressed in specific neuronal populations, including GABAergic interneurons that are essential regulators of cortical circuits 3. These SST-positive interneurons can be generated from human stem cells for potential therapeutic applications in neurological disorders 4. Clinically, long-acting SST analogs like octreotide and lanreotide are used to treat conditions involving excessive hormone release, such as acromegaly and Cushing's syndrome 1.