SSX2IP (SSX family member 2 interacting protein) is a multifunctional protein that serves as a critical microtubule-anchoring factor at centrosomes and plays essential roles in cell organization and movement. The protein localizes to centrosomes in a centriolar satellite-dependent manner and binds the microtubule-nucleator γ-tubulin complex, ensuring proper microtubule anchoring 1. SSX2IP is essential for maintaining spindle orientation during mitosis and proper centriole assembly and duplication 12. Beyond centrosome function, SSX2IP is required for ciliogenesis and proper ciliary function, with knockdown resulting in ciliary defects and disturbed left-right asymmetry during embryogenesis 1. The protein also plays roles in cellular adhesion systems and cell movement 3. Clinically, SSX2IP has emerged as a significant factor in cancer biology, with high expression levels associated with aggressive pathological features and worse oncological outcomes in nasopharyngeal carcinoma 4 and hepatocellular carcinoma 5. In breast cancer, SSX2IP promotes cell proliferation and migration through regulation of FANCI 6. Additionally, SSX2IP contributes to mTORC1 signaling and nutrient sensing through lysosome positioning regulation 7.