WRAP73 (WDR8) is a WD-repeat protein that functions as a centriolar satellite protein with critical roles in centrosome organization and ciliogenesis. As part of the SSX2IP:WRAP73 complex, it regulates spindle anchoring at the mitotic centrosome and is required for normal bipolar spindle morphology 1. WRAP73 mediates the centrosomal localization of multiple centriolar satellite proteins including SSX2IP, PCM1, CEP290, and PIBF1, and interacts with the centriolar protein CEP135 23. During ciliogenesis, WRAP73 is essential for ciliary vesicle docking to the mother centriole and removal of the CEP97:CCP110 ciliary inhibitory complex, likely promoting docking of RAB8A- and ARL13B-containing vesicles 2. Functionally, loss of WRAP73 is compensated for in mitotic progression, though its absence affects normal interphase centrosome function 3. Pathologically, mutations in WRAP73 cause isolated microspherophakia, an autosomal recessive lens disorder, with the p.Pro383Leu missense mutation rendering the protein unstable and disrupting binding partner interactions 4. Additionally, WRAP73 methylation patterns associate with Crohn's disease pathogenesis and osteoporosis risk, suggesting epigenetic involvement in inflammatory and metabolic bone diseases 56.