STAB2 (stabilin-2) is a multifunctional scavenger receptor primarily expressed in liver and spleen that mediates clearance of diverse plasma ligands through receptor-mediated endocytosis 1. As a phosphatidylserum receptor, STAB2 facilitates apoptotic cell engulfment and functions as a hyaluronic acid receptor regulating extracellular matrix turnover 2. The receptor binds multiple glycosaminoglycans, advanced glycation end-products, and hemostatic proteins including fibrinogen, plasminogen, and heparin cofactor II, internalizing these ligands to lysosomes for degradation 3. STAB2 also serves immunological roles, binding Gram-positive and Gram-negative bacteria and supporting lymphocyte recruitment in hepatic vasculature 2. Genetically, STAB2 emerged as a pleiotropic locus associated with 41 plasma protein abundances in large-scale proteogenomic studies, with rare variants showing predominantly loss-of-function effects 4. Damaging STAB2 variants are significantly associated with venous thromboembolism risk, present in 7.8% of VTE cases versus 2.4% of controls 1. Disease mechanism involves haploinsufficiency leading to reduced clearance of procoagulant proteins and elevated circulating von Willebrand factor and coagulation factor VIII levels 5. STAB2 expression is regulated by master transcription factors in mesenchymal stromal cells, suggesting broader developmental and differentiation roles 6.