STK24 is a serine/threonine kinase belonging to the MST (mammalian sterile twenty) family that regulates multiple cellular processes through phosphorylation of downstream targets. Primary functions include promotion of stress-induced apoptosis by modulating JNK and p38 MAPK phosphorylation during oxidative stress, and regulation of the STRIPAK complex involved in Hippo and MAPK signaling 1. STK24 also modulates excitatory synaptic transmission in hippocampal neurons, with reduced expression observed in epileptic tissue 2. In cancer biology, STK24 promotes lung adenocarcinoma (LUAD) progression through multiple mechanisms: it enhances cell proliferation and migration while suppressing apoptosis, acts downstream of the transcription factor KLF5, and activates the STAT3/VEGFA angiogenesis pathway 34. STK24 was identified as a LUAD risk locus through genome-wide association studies, with high expression correlating with poor patient prognosis 5. In hepatocellular carcinoma, STK24 activates the stress-responsive MASTL/YBX1/PAK4 axis driving lenvatinib resistance 6. Clinically, STK24 and its partner kinase STK25 inhibit cerebral cavernous malformation development, as their combined deficiency phenocopies CCM3 loss 7. The KLF5/STK24 and STK24/STAT3/VEGFA axes represent potential therapeutic targets for cancer treatment.