STOM (stomatin) is a 31-kDa integral membrane protein that functions as a regulator of ion channel activity and transmembrane ion transport 1. The protein contains a single hydrophobic domain and localizes to membrane rafts and other membrane compartments 2. STOM modulates ion channel activity, particularly ASIC2 and ASIC3 channels, and exists as an oligomeric complex 2. The protein's physiological role includes regulation of sodium and potassium ion transport in red blood cells, with mutations or absence associated with hereditary stomatocytosis 1. Mechanistically, STOM functions as a positive regulator of osteoclast differentiation by interacting with Prdx1, promoting its lysosomal degradation and increasing intracellular reactive oxygen species (ROS) production 3. In bone physiology, STOM expression is elevated in osteoporosis patients and ovariectomized mice, and STOM-deficient mice exhibit higher bone mass 3. Clinically, STOM has emerged as a therapeutic target in multiple diseases. Elevated STOM expression correlates with osteoporosis severity, making it a candidate for therapeutic inhibition to ameliorate pathological bone remodeling 3. STOM was identified as a glial therapeutic target in progressive supranuclear palsy through cross-species systems biology validation 4. Additionally, STOM functions in ccRCC progression through regulation of endothelial cell-derived growth factor signaling 5 and serves as a prognostic biomarker in osteosarcoma and DLBCL 67.