ASIC1 (acid-sensing ion channel subunit 1) functions as a proton-gated cation channel that responds to acidic pH by conducting sodium and calcium ions across cell membranes 1. The channel plays critical roles in multiple pathophysiological processes through pH-dependent activation. In atherosclerosis, ASIC1 accelerates disease progression by interacting with RIP1 to disrupt lipophagy in macrophages, leading to increased lipid accumulation 2. In stroke pathophysiology, glutamate acts as a positive allosteric modulator of ASIC1a, increasing its proton affinity and exacerbating ischemic neurotoxicity beyond traditional NMDAR-mediated mechanisms 3. ASIC1 contributes to cellular senescence in nucleus pulposus mesenchymal stem cells during intervertebral disc degeneration through activation of p53-p21/p27 and p16-Rb1 signaling pathways 4. The channel is expressed in sensory fibers of the human oropharynx and is implicated in dry eye disease pathogenesis 56. Therapeutically, ASIC1a inhibition shows cardioprotective effects against ischemia-reperfusion injury, improving cardiac viability through mechanisms independent of baseline electromechanical coupling 7. These findings establish ASIC1 as a key mediator of acid-induced cellular damage across multiple organ systems.