SYT11 (synaptotagmin-11) is a non-calcium-binding vesicular trafficking protein that regulates exo-endocytosis and synaptic function through multiple mechanisms. Unlike calcium-sensitive synaptotagmins, SYT11 exhibits calcium-inhibited lipid binding and competes with calcium-binding Syt1 for membrane occupancy, thereby inhibiting both early exocytosis and endocytosis stages while preserving maximal exocytotic rates 1. SYT11 functions as a vesicular scaffold protein, facilitating assembly of presynaptic signaling complexes including GABAB receptors and Cav2.2 calcium channels in post-Golgi vesicles, and stabilizing these complexes at the neuronal plasma membrane 2. In dopaminergic neurons, SYT11 regulates dopamine vesicle recycling and endocytosis. SYT11 deficiency in early adolescence causes dopamine over-transmission, leading to schizophrenia-like behavioral deficits including social withdrawal, which can be reversed by D2 receptor antagonists 3. SYT11 expression is reduced in schizophrenia patients but restored after antipsychotic treatment. Beyond neuronal functions, SYT11 participates in vesicular trafficking control affecting cancer cell invasion and metastasis 4 and is linked genetically to Parkinson's disease, where palmitoylation-mediated increases in SYT11 abundance promote pathological α-synuclein aggregation 5. Additionally, SYT11 is implicated in atherosclerosis pathogenesis through plasma proteomic analysis 6.