TBC1D12 is a RAB11A-binding protein with established roles in neurite outgrowth and autophagy regulation. At the molecular level, TBC1D12 functions as a GTPase activator associated with recycling endosomes and autophagosome assembly 1. Computationally, TBC1D12 was identified as an autophagy-related gene not previously characterized in cancer pathways 1. Clinically, TBC1D12 has emerged as a significant disease biomarker across multiple conditions. In anaplastic thyroid cancer, TBC1D12 5'UTR mutations occur in 50% of cases and associate with aggressive features including advanced tumor stage, older age at diagnosis, and higher pathological T3/T4 classification 2. TBC1D12 was identified as a core diagnostic marker for recurrent miscarriage, contributing to a predictive nomogram with high ROC/calibration curve performance 3. In bladder cancer, TBC1D12 non-coding hotspot mutations function as urinary biomarkers, detecting incident disease with 66% sensitivity and 92% specificity 4. Additionally, TBC1D12 emerged as a hub gene shared between type 2 diabetes mellitus and asthenozoospermia, with altered expression in sperm from diabetic patients with poor motility 5. Expression dysregulation was also observed in prostate cancer and Parkinson disease, supporting an inverse comorbidity relationship between these conditions 6.