TECPR2 (tectonin beta-propeller repeat containing 2) is a protein localized to chromosome 14 that functions as a positive regulator of autophagy [UniProt annotation]. The protein is involved in protein exit from the endoplasmic reticulum, suggesting a role in cellular protein trafficking and quality control mechanisms. Mutations in TECPR2 cause hereditary sensory and autonomic neuropathy 9 with developmental delay, indicating critical functions in neuronal development and maintenance. Given TECPR2's role in autophagy regulation, its disease association is mechanistically relevant, as autophagy dysfunction has been implicated in numerous human pathologies 1. Autophagy serves as a cellular safeguard mechanism, including the autophagic disposal of damaged mitochondria to prevent inflammatory responses 2. The loss of TECPR2 function likely impairs this protective autophagy pathway, potentially leading to accumulation of cellular damage and neuroinflammation. The developmental delay phenotype suggests TECPR2 is particularly essential during neurogenesis and axonal development, where efficient protein quality control and mitochondrial homeostasis are critical. Understanding TECPR2's specific autophagy-regulatory mechanisms may provide insights into neuropathy pathogenesis and potentially identify therapeutic targets for hereditary sensory and autonomic neuropathies.