TGOLN2 (trans-Golgi network protein 2) is a membrane trafficking protein localized to the trans-Golgi network that regulates vesicular transport between the Golgi apparatus and other cellular compartments. TGOLN2 functions as a marker protein for the trans-Golgi network and participates in autophagy regulation; RAB2 engages TGOLN2-containing structures during the formation of autophagosomes and autolysosomes, connecting Golgi-derived membrane delivery to autophagy machinery 1. The protein is involved in lysosomal physiology and can be identified in proteomic studies of lysosomal compartments 2. TGOLN2 has emerging clinical significance in cancer biology and metastatic disease. A germline variant (rs112065068) in TGOLN2 is associated with high risk of distant metastasis in non-small cell lung cancer patients and predicts worse metastasis-free survival (HR=4.19) 3. Bioinformatics analyses identify TGOLN2 as a putative broad-spectrum cancer tumor suppressor 4 and as a hub gene in irinotecan resistance in colorectal cancer 5. TGOLN2 expression is also dysregulated in abdominal aortic aneurysm pathogenesis, where it appears as a key hub gene in early disease stages 6. These findings suggest TGOLN2 functions beyond canonical membrane trafficking, with potential roles in cancer progression and vascular disease.