GOLGA4 (golgin A4) is a dimeric Golgi matrix protein primarily involved in vesicular trafficking and Golgi apparatus organization. It participates in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through interaction with MACF1, and mediates endosome-to-Golgi trafficking 1. GOLGA4 forms a functional complex with RAB3D GTPase and MYH10 at the trans-Golgi network under normal conditions 2. Notably, GOLGA4 is dispensable for spermatogenesis and male fertility, as Golga4 knockout mice demonstrate normal testicular morphology and fertility 3. In disease contexts, GOLGA4 plays significant roles in malignancy and liver pathology. Alcohol-induced Golgi dysfunction triggers GOLGA4-mediated phagophore formation through conformational changes and RAB3D downregulation, contributing to alcohol-associated liver disease pathogenesis 2. GOLGA4 serves as a recurrent fusion partner in oncogenic rearrangements: GOLGA4-JAK2 fusions drive B-cell acute lymphoblastic leukemia through constitutive JAK/STAT signaling activation and respond to JAK inhibitors 4; GOLGA4-RAF1 fusions activate MAPK signaling in pancreatic acinar cell carcinomas 5, infantile fibrosarcomas 6, and melanomas with dramatic MEK inhibitor responses 7. Additionally, GOLGA4 functions as a tumor-associated autoantigen in renal cell carcinoma, with concomitant GOLGA4 vaccination enhancing anti-tumor immunity 8.