TMC2 (transmembrane channel-like 2) is a pore-forming subunit of the mechanotransducer (MET) ion channel complex located at stereocilia tips in cochlear and vestibular hair cells 1. TMC2 functions as a mechanically-gated, non-selective cation channel that converts mechanical vibrations into electrical signals essential for auditory mechanotransduction 23. The channel is highly permeable to calcium and transports monovalent cations, responding to tension in tip-links connecting stereocilia 4. TMC2 operates as a pore-forming subunit alone or as part of a dimeric complex 5, with activity modulated by auxiliary proteins including TMIE, CIB2, LHFPL5, and PCDH15 67. Mutations in TMC2 disrupt mechanotransduction and cause hearing loss, with deafness-related variants altering ion selectivity properties 2. TMC2 also participates in vestibular mechanotransduction, contributing to balance and spatial orientation 4. The channel's subcellular localization and functional assembly depend on interactions with regulatory proteins, though TMC2 shows greater developmental flexibility than TMC1 regarding these cofactors 8.