TMEM201 (transmembrane protein 201) is an inner nuclear membrane protein with diverse cellular functions spanning nuclear organization, cell migration, and oncogenesis. As a structural component, TMEM201 interacts with the LINC complex and nuclear lamins to organize nuclear envelope architecture 1 2. The protein exhibits dual functionality during cell division, where it localizes to mitotic spindles and directly binds γ-tubulin to facilitate proper spindle assembly and chromosome 1 3. In vascular biology, TMEM201 promotes endothelial cell migration and angiogenesis through its interaction with the LINC complex, with knockout studies in mice and zebrafish demonstrating impaired vessel development 1. The protein also regulates stem cell differentiation, as ectopic expression rapidly induces iPSC differentiation toward neuronal lineages 4. In cancer contexts, TMEM201 functions as an oncogenic factor, promoting breast cancer metastasis by physically interacting with SMAD2/3 proteins and enhancing TGFβ signaling-mediated epithelial-to-mesenchymal transition 5. Additionally, TMEM201 has been identified as a prognostic biomarker in uveal melanoma and hepatocellular carcinoma, where high expression correlates with poor patient outcomes 6 7. These findings establish TMEM201 as a multifunctional nuclear envelope protein critical for cellular organization, vascular development, and cancer progression.