Based on limited published evidence, TMEM86B encodes a lysoplasmalogenase that catalyzes hydrolysis of the vinyl ether bond in choline and ethanolamine lysoplasmalogens, producing fatty aldehyde and glycerophosphocholine or glycerophosphoethanolamine 1. The enzyme is specific for sn-2-deacylated plasmalogen forms and shows apparent Km values of ~50 μM for both substrates with pH optimum of 7.0 1. TMEM86B localizes to membrane fractions, with highest expression in liver and duodenum 2. Overexpression decreases cellular plasmalogen levels, suggesting a regulatory role in plasmalogen homeostasis 1.