TRAPPC5 is a subunit of the TRAPP (trafficking protein particle) complex, which functions as a tethering complex involved in vesicular transport. TRAPPC5 likely plays a role in endoplasmic reticulum to Golgi vesicle-mediated transport and COPII vesicle coating 1. The protein associates with other TRAPP subunits including TPC6 and BET3 through heterodimerization, forming a family of paralogous proteins with conserved three-dimensional structures despite low sequence similarity 1. At the molecular level, TRAPPC5 participates in vesicle tethering and protein binding functions within the cytoplasm and cytosol, contributing to intracellular membrane trafficking networks 1. Clinical relevance of TRAPPC5 has emerged in pediatric sepsis research. A comprehensive microarray analysis identified dysregulation of lncRNA lnc-TRAPPC5-1 in pediatric sepsis patients compared to healthy controls, with this lncRNA co-expressing with mRNAs DYSF and HLX 2. These aberrant expression patterns were validated by quantitative real-time PCR, suggesting TRAPPC5-related transcripts may represent potential candidate biomarkers for sepsis diagnosis and treatment 2. However, the mechanistic link between TRAPPC5 dysfunction and sepsis pathogenesis requires further investigation.