TRAPPC2B — trafficking protein particle complex subunit 2B

5 sources retrieved · Most recent: April 2026 · Index updated 5 months ago

21PubMed Papers

#13,860 · top 71% of 19K genes

20Diseases

top 72%

0Drugs

0Pathogenic Variants

TransporterExperimental GO EvidenceSwiss-Prot Reviewed

nuclear outer membranetranscription corepressor bindingtranscription regulator inhibitor activityprotein bindingCongenital pulmonary alveolar proteinosischronic obstructive pulmonary diseasebutyrylcholinesterase deficiencycongenital lobar emphysema

AI Summary

AI summary not yet available. Showing NCBI Gene summary.

trafficking protein particle complex subunit 2B

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.

Disease Associations20

Congenital pulmonary alveolar proteinosisOpen Targets

0.07Suggestive

chronic obstructive pulmonary diseaseOpen Targets

0.07Suggestive

butyrylcholinesterase deficiencyOpen Targets

0.07Suggestive

congenital lobar emphysemaOpen Targets

0.05Suggestive

laryngeal abductor paralysis-intellectual disability syndromeOpen Targets

0.05Suggestive

congenital laryngomalaciaOpen Targets

0.05Suggestive

LaryngomalaciaOpen Targets

0.05Suggestive

bronchiolitis obliterans syndromeOpen Targets

0.05Suggestive

pulmonary alveolar microlithiasisOpen Targets

0.05Suggestive

interstitial lung disease 1Open Targets

0.05Suggestive

pulmonary fibrosis and/or bone marrow failure, Telomere-related, 3Open Targets

0.05Suggestive

asthmaOpen Targets

0.05Suggestive

benign neoplasm of eyeOpen Targets

0.05Suggestive

primary ciliary dyskinesiaOpen Targets

0.04Suggestive

Neonatal acute respiratory distress with surfactant metabolism deficiencyOpen Targets

0.04Suggestive

pulmonary arterial hypertensionOpen Targets

0.04Suggestive

pulmonary hypertension, primary, 3Open Targets

0.04Suggestive

ovarian neoplasmOpen Targets

0.02Suggestive

neoplasmOpen Targets

0.02Suggestive

SepsisOpen Targets

0.01Suggestive

Pathogenic Variants

No pathogenic variants reported on ClinVar for this gene.

Tissue Expression6 tissues

Brain

100%

Heart

95%

Bone Marrow

70%

Ovary

67%

Lung

59%

Liver

45%

Gene Interaction Network6 neighbors

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StructureAlphaFold

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AlphaFoldAI-predicted · UniProt P0DI82

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ConstraintgnomAD v4.1

LOEUFⓘ

1.30LoF Tolerant

pLIⓘ

0.05Tolerant

Observed/Expected LoF0.62 [0.32–1.30]

Rankings2 dim

Where TRAPPC2B stands among ~20K protein-coding genes

#14,049of 20,598
Most Researched21
#13,707of 17,882
Most Constrained (LOEUF)1.30