TRAPPC2B — trafficking protein particle complex subunit 2B

5 sources retrieved · Most recent: April 2026 · Index updated 3 months ago

21PubMed Papers

#13,860 · top 71% of 19K genes

20Diseases

top 72%

0Drugs

0Pathogenic Variants

TransporterExperimental GO EvidenceSwiss-Prot Reviewed

nuclear outer membranetranscription corepressor bindingtranscription regulator inhibitor activityprotein bindingFuchs endothelial corneal dystrophycongenital hereditary endothelial dystrophy of corneasnowflake vitreoretinal degenerationcorneal endothelial dystrophy

AI Summary

AI summary not yet available. Showing NCBI Gene summary.

trafficking protein particle complex subunit 2B

⚠Limited data available — This gene has 0 indexed publications. Summary and analysis may be incomplete.

Disease Associations20

Fuchs endothelial corneal dystrophyOpen Targets

0.05Suggestive

congenital hereditary endothelial dystrophy of corneaOpen Targets

0.05Suggestive

snowflake vitreoretinal degenerationOpen Targets

0.04Suggestive

corneal endothelial dystrophyOpen Targets

0.04Suggestive

benign neoplasm of eyeOpen Targets

0.04Suggestive

isolated congenital megalocorneaOpen Targets

0.04Suggestive

megalocorneaOpen Targets

0.04Suggestive

early-onset non-syndromic cataractOpen Targets

0.04Suggestive

Familial ocular anterior segment mesenchymal dysgenesisOpen Targets

0.04Suggestive

keratoconus 9Open Targets

0.04Suggestive

keratoconus 1Open Targets

0.04Suggestive

Leber congenital amaurosis 8Open Targets

0.03Suggestive

macular corneal dystrophyOpen Targets

0.03Suggestive

Testicular regression syndromeOpen Targets

0.03Suggestive

keratoconus 5Open Targets

0.03Suggestive

46,XX ovotesticular disorder of sex developmentOpen Targets

0.03Suggestive

congenital stromal corneal dystrophyOpen Targets

0.03Suggestive

cornea plana 2Open Targets

0.03Suggestive

congenital primary aphakiaOpen Targets

0.03Suggestive

Leber congenital amaurosis 4Open Targets

0.03Suggestive

Pathogenic Variants

No pathogenic variants reported on ClinVar for this gene.

Tissue Expression6 tissues

Brain

100%

Heart

95%

Bone Marrow

70%

Ovary

67%

Lung

59%

Liver

45%

Gene Interaction Network6 neighbors

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StructureAlphaFold

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AlphaFoldAI-predicted · UniProt P0DI82

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ConstraintgnomAD v4.1

LOEUFⓘ

1.30LoF Tolerant

pLIⓘ

0.05Tolerant

Observed/Expected LoF0.62 [0.32–1.30]

Rankings2 dim

Where TRAPPC2B stands among ~20K protein-coding genes

#14,049of 20,598
Most Researched21
#13,707of 17,882
Most Constrained (LOEUF)1.30