TRIM36 is an E3 ubiquitin ligase that functions as a microtubule-associated protein involved in cellular organization and protein degradation 1. As a member of the TRIM family containing a RING finger domain, TRIM36 mediates K48-linked polyubiquitination of target proteins, promoting their proteasomal degradation 2. The protein plays critical roles in cytoskeletal organization, cell cycle progression, and coordinates microtubule dynamics at the plus end 1. TRIM36 is also implicated in male fertility through involvement in the spermatozoa acrosome reaction 1. Clinically, TRIM36 functions as a tumor suppressor across multiple cancer types. In colorectal cancer, TRIM36 suppresses FOXA2 via ubiquitination, activating the NRF2/GPX4 ferroptosis pathway to inhibit tumor progression 2. In esophageal squamous cell carcinoma, TRIM36 promotes apoptosis and inhibits proliferation by ubiquitinating β-catenin to suppress Wnt signaling 3. TRIM36 enhances lung adenocarcinoma radiosensitivity through RAD51 ubiquitination 4, while in prostate cancer, it suppresses neuroendocrine differentiation via HK2 ubiquitination 5. Biallelic TRIM36 mutations cause anencephaly, a severe neural tube closure defect 1. Notably, TRIM36 is frequently hypermethylated and downregulated in lung cancers exposed to polycyclic aromatic hydrocarbons, correlating with carcinogenic progression 6.