TRIP13 (thyroid hormone receptor interactor 13) is an AAA+ ATPase that plays critical roles in DNA repair, chromosome 5, and cell cycle regulation 1. The protein functions in DNA double-strand break repair by promoting early repair steps upstream of RAD51 complex assembly and regulates mitotic spindle assembly checkpoint signaling 2. TRIP13 controls shieldin complex activity through interactions with MAD2L2, requiring appropriate protein levels for proper shieldin assembly and disassembly during DNA repair 2. In cancer, TRIP13 acts as an oncogene with aberrant expression observed across multiple malignancies including gastric cancer, triple-negative breast cancer, and HPV-driven cancers 345. High TRIP13 expression correlates with poor prognosis and advanced tumor stages 6. Mechanistically, TRIP13 promotes cancer progression through various pathways, including stabilizing DDX21 expression in gastric cancer and forming complexes with USP7/c-FLIP in breast cancer 34. TRIP13 also contributes to oocyte maturation, with mutations causing oocyte/embryo maturation arrest 7. The protein represents a promising therapeutic target, with several small-molecule inhibitors showing anticancer efficacy 15.