TEX11 is an X-linked, meiosis-specific gene essential for male fertility that regulates crossing-over during meiosis 1. The protein functions as a regulator of meiotic recombination and chrX synapsis, promoting genome-wide recombination rates and facilitating the initiation and maintenance of chromosome X 2. TEX11 is strongly expressed in spermatogonia and weakly in spermatocytes 1, with localization in late-pachytene spermatocytes and round spermatids 3. Mechanistically, TEX11 deficiency causes abnormal meiotic recombination and impaired chrX synapsis, leading to meiotic arrest and failure of post-meiotic spermatid development 4. TEX11 mutations cause non-obstructive azoospermia (NOA), occurring in approximately 1% of azoospermic men, with various pathogenic variants identified including frameshift, missense, and splicing mutations 2. Histological analyses reveal meiotic arrest with absent post-meiotic spermatids and spermatozoa in seminiferous tubules 14. Clinically, TEX11 mutations are associated with male infertility and azoospermia, and the gene should be included in genetic screening panels for clinical evaluation of infertile men 35. Notably, TEX11 also exhibits tumor-suppressive properties in colorectal cancer through regulation of the FOXO3a/COP1/c-Jun/p21 axis 6.