Based on limited published evidence, TRMT44 encodes a probable adenosyl-L-methionine (AdoMet)-dependent tRNA methyltransferase with tRNA (uridine) methyltransferase activity. The protein catalyzes methylation of uracil residues in transfer RNA molecules, a post-transcriptional modification essential for tRNA function. TRMT44 was identified as a hub gene in co-expression network analysis associated with recurrent early pregnancy loss, suggesting potential involvement in reproductive processes 1, though the mechanistic connection to pregnancy loss remains unclear.