Based on limited published evidence, TSPY3 is a testis-specific Y-linked gene that may be involved in sperm differentiation and proliferation. Structurally, it localizes to the nucleus and possesses chrY and histone binding properties. TSPY3 serves as a reliable male-specific genetic marker for sex identification in human samples, including ancient skeletal remains 1. The gene exhibits differential expression in the endometrium, with elevated levels observed in infertile patients compared to fertile controls, suggesting potential involvement in reproductive pathology 2.